MovDisordV3, Main, Exploration, bibRecord, 003C95

Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD

Identifieur interne : 003C95 ( Main/Exploration ); précédent : 003C94; suivant : 003C96

Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD

Auteurs : Jürgen Andrich [Allemagne] ; Carsten Saft [Allemagne] ; Anneliese Arz [Allemagne] ; Birgit Schneider [Allemagne] ; Markus W. Agelink [Allemagne] ; Peter H. Kraus [Allemagne] ; Wilfried Kuhn [Allemagne] ; Thomas Müller [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2004-02.

RBID : ISTEX:4BAF0240DD74950C3471FB24A5DF43A7F144CB77

Descripteurs français

Pascal (Inist)
- Chorée Huntington, Homme, Système nerveux pathologie, Traitement.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Biological Markers (blood), Central Nervous System Agents (administration & dosage), Central Nervous System Agents (adverse effects), Central Nervous System Agents (pharmacokinetics), Disease Progression, Drug Interactions, Female, Homocysteine (blood), Human, Humans, Huntington Disease (blood), Huntington Disease (diagnosis), Huntington Disease (drug therapy), Huntington disease, Huntington's disease, Hyperhomocysteinemia (blood), Hyperhomocysteinemia (diagnosis), Male, Metabolic Clearance Rate (drug effects), Middle Aged, Mutation (genetics), Nerve Tissue Proteins (genetics), Nervous system diseases, Neurologic Examination, Nuclear Proteins (genetics), Treatment, homocysteine, neurodegeneration.
MESH :
- chemical , administration & dosage : Central Nervous System Agents.
- chemical , adverse effects : Central Nervous System Agents.
- chemical , blood : Biological Markers, Homocysteine.
- chemical , genetics : Nerve Tissue Proteins, Nuclear Proteins.
- chemical , pharmacokinetics : Central Nervous System Agents.
- blood : Huntington Disease, Hyperhomocysteinemia.
- diagnosis : Huntington Disease, Hyperhomocysteinemia.
- drug effects : Metabolic Clearance Rate.
- drug therapy : Huntington Disease.
- genetics : Mutation.
- Adult, Disease Progression, Drug Interactions, Female, Humans, Male, Middle Aged, Neurologic Examination.

Abstract

Significantly increased plasma total homocysteine levels (t‐Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine β‐synthase, we hypothesize that homocysteine promotes neurodegeneration in HD. © 2003 Movement Disorder Society

Url:

https://api.istex.fr/document/4BAF0240DD74950C3471FB24A5DF43A7F144CB77/fulltext/pdf

DOI: 10.1002/mds.10629

Affiliations:

Allemagne

Le document en format XML

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<author><name sortKey="Saft, Carsten" sort="Saft, Carsten" uniqKey="Saft C" first="Carsten" last="Saft">Carsten Saft</name>
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<author><name sortKey="Arz, Anneliese" sort="Arz, Anneliese" uniqKey="Arz A" first="Anneliese" last="Arz">Anneliese Arz</name>
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<author><name sortKey="Schneider, Birgit" sort="Schneider, Birgit" uniqKey="Schneider B" first="Birgit" last="Schneider">Birgit Schneider</name>
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<author><name sortKey="Kraus, Peter H" sort="Kraus, Peter H" uniqKey="Kraus P" first="Peter H." last="Kraus">Peter H. Kraus</name>
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<author><name sortKey="Kuhn, Wilfried" sort="Kuhn, Wilfried" uniqKey="Kuhn W" first="Wilfried" last="Kuhn">Wilfried Kuhn</name>
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<front><div type="abstract" xml:lang="en">Significantly increased plasma total homocysteine levels (t‐Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine β‐synthase, we hypothesize that homocysteine promotes neurodegeneration in HD. © 2003 Movement Disorder Society</div>
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<name sortKey="Kraus, Peter H" sort="Kraus, Peter H" uniqKey="Kraus P" first="Peter H." last="Kraus">Peter H. Kraus</name>
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<name sortKey="Schneider, Birgit" sort="Schneider, Birgit" uniqKey="Schneider B" first="Birgit" last="Schneider">Birgit Schneider</name>
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Movement Disorders (revue)

Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD

Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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